MolNFT v1 · #36809 · protein

Crystal structure of the phosphatase domains of human ptp sigma

2FH7 · Receptor-type tyrosine-protein phosphatase S: “Crystal structure of the phosphatase domains of human ptp sigma”. X-ray diffraction, 8 pockets (best druggability 0.79). MolNFT v1 #36809 on GenesisL1: 3D structure, binding sites and…

PDB: 2FH7
Type: protein
Length: 568 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-type tyrosine-protein phosphatase S
EC: 3.1.3.48
UniProt: Q13332
Pockets: 8 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase S (EC 3.1.3.48)	protein	568	35% helix, 23% strand	Q13332

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	211	0.79	0.93	27	empty
2	218	0.58	0.80	24	empty
3	203	0.55	0.79	21	empty
4	180	0.51	0.77	22	empty
5	123	0.46	0.78	25	empty

Compared structures

2FH7 · Crystal structure of the phosphatase domains of human PTP SIGMA · the same entry in another collection · chain A against A, TM-score 1.00
Q13332 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase S… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13332
Elsewhere: RCSB PDB 2FH7 · PDBe 2FH7 · UniProt Q13332

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.