MolNFT v1 · #36789 · protein

Structural studies examining the substrate specificity profiles of pc- plcbc protein variants

2FGN · Phospholipase C: “Structural studies examining the substrate specificity profiles of pc- plcbc protein variants”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.45). MolNFT v1 #36789 on GenesisL1: 3D structure…

PDB: 2FGN
Type: protein
Length: 243 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phospholipase C
EC: 3.1.4.3
UniProt: P09598
Ligands: ZN
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 65% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phospholipase C (EC 3.1.4.3)	protein	243	65% helix, 1% strand	P09598

Ligands and binding sites

ZN · Zinc ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	125	0.45	0.78	22	empty

Compared structures

2FGN · Structural Studies Examining the Substrate Specificity Profiles of PC-PLCBc Protein… · the same entry in another collection · chain A against A, TM-score 1.00
P09598 · AlphaFold monomer V2.0 prediction for phospholipase C (P09598) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09598
Elsewhere: RCSB PDB 2FGN · PDBe 2FGN · UniProt P09598

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