MolNFT v1 · #36630 · protein

Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex at 2.8 ångströms resolution

2FBP · Fructose 1,6-bisphosphatase: “Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex at 2.8…”. X-ray diffraction, 10 pockets (best druggability 0.53). MolNFT v1 #36630 on GenesisL1: 3D…

PDB: 2FBP
Type: protein
Length: 632 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fructose 1,6-bisphosphatase
EC: 3.1.3.11
UniProt: P00636
Pockets: 10 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Fructose 1,6-bisphosphatase (EC 3.1.3.11)	protein	316	34% helix, 25% strand	P00636

Pockets

10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	224	0.53	0.77	38	empty
2	157	0.46	0.76	21	empty
3	110	0.45	0.78	18	empty
4	119	0.42	0.77	24	empty
5	111	0.42	0.77	21	empty

Interfaces

1 interface between chains.

A–B · 2030 Å² buried · 36 hydrogen bonds · protein-protein

Compared structures

2FBP · Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate… · the same entry in another collection · chain A against A, TM-score 1.00
P00636 · AlphaFold monomer V2.0 prediction for fructose-1,6-bisphosphatase 1 (P00636) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00636
Elsewhere: RCSB PDB 2FBP · PDBe 2FBP · UniProt P00636

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