MolNFT v1 · #36628 · protein
Plasmodium falciparum putative FK506-binding protein PFL2275C, C-terminal tpr-containing domain
2FBN · 70 kda peptidylprolyl isomerase, putative: “Plasmodium falciparum putative FK506-binding protein PFL2275C, C-terminal tpr-containing domain”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #36628 on GenesisL1: 3D…
- PDB
- 2FBN
- Type
- protein
- Length
- 304 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 70 kda peptidylprolyl isomerase, putative
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 70 kda peptidylprolyl isomerase, putative | protein | 153 | 78% helix, 0% strand | — |
| B | 70 kda peptidylprolyl isomerase, putative | protein | 151 | 80% helix, 0% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 865 | 0.73 | 0.78 | 67 | empty |
| 2 | 64 | 0.31 | 0.75 | 15 | empty |
| 3 | 54 | 0.28 | 0.74 | 13 | empty |
| 4 | 52 | 0.27 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 951 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2FBN · Plasmodium falciparum putative FK506-binding protein PFL2275c, C-terminal TPR-containing… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2FBN · PDBe 2FBN
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