MolNFT v1 · #36536 · protein
A native to amyloidogenic transition regulated by a backbone trigger
2F8O · Beta-2-microglobulin: “A native to amyloidogenic transition regulated by a backbone trigger”. X-ray diffraction, 1 pocket (best druggability 0.64). MolNFT v1 #36536 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2F8O
- Type
- protein
- Length
- 188 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-2-microglobulin
- UniProt
- P61769
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 0% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Beta-2-microglobulin | protein | 94 | 0% helix, 54% strand | P61769 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 548 | 0.64 | 0.75 | 48 | empty |
Interfaces
1 interface between chains.
- A–B · 273 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2F8O · A Native to Amyloidogenic Transition Regulated by a Backbone Trigger · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 2F8O · PDBe 2F8O · UniProt P61769
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