MolNFT v1 · #36494 · protein

A mutant rabbit cathepsin K with a nitrile inhibitor

2F7D: “A mutant rabbit cathepsin K with a nitrile inhibitor”. X-ray diffraction, 1 ligand (NOQ). MolNFT v1 #36494 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2F7D
Type: protein
Length: 215 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cathepsin K
EC: 3.4.22.38
UniProt: P43236
Ligands: NOQ

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cathepsin K (EC 3.4.22.38)	protein	215	31% helix, 22% strand	P43236

Ligands and binding sites

NOQ · (1R,2R)-N-(2-aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 3 disulfide, 1 covalent (disulfide, covalent ligand).

Compared structures

2F7D · A mutant rabbit cathepsin K with a nitrile inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
P43236 · AlphaFold monomer V2.0 prediction for cathepsin K (P43236) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43236
Elsewhere: RCSB PDB 2F7D · PDBe 2F7D · UniProt P43236

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.