MolNFT v1 · #36470 · protein
X-ray structure of chorismate mutase from mycobacterium tuberculosis
2F6L: “X-ray structure of chorismate mutase from mycobacterium tuberculosis”. X-ray diffraction, 3 pockets (best druggability 0.71). MolNFT v1 #36470 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2F6L
- Type
- protein
- Length
- 330 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chorismate mutase
- EC
- 5.4.99.5
- UniProt
- O07746
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chorismate mutase (EC 5.4.99.5) | protein | 166 | 72% helix, 0% strand | O07746 |
| B | Chorismate mutase (EC 5.4.99.5) | protein | 164 | 76% helix, 0% strand | O07746 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.71 | 0.96 | 18 | empty |
| 2 | 212 | 0.64 | 0.83 | 22 | empty |
| 3 | 181 | 0.48 | 0.76 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 845 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2F6L · X-ray structure of Chorismate Mutase from Mycobacterium Tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O07746
- Elsewhere: RCSB PDB 2F6L · PDBe 2F6L · UniProt O07746
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