MolNFT v1 · #36382 · protein
Crystal structure of fapr (in complex with effector)- a global regulator of fatty acid biosynthesis in B. subtilis
2F3X · Transcription factor fapr: “Crystal structure of fapr (in complex with effector)- a global regulator of fatty acid biosynthesis in B.…”. X-ray diffraction, 1 ligand (MLC), 2 pockets (best druggability 0.64). MolNFT v1 #36382 on…
- PDB
- 2F3X
- Type
- protein
- Length
- 286 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription factor fapr
- UniProt
- O34835
- Ligands
- MLC
- Pockets
- 2 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transcription factor fapr | protein | 143 | 28% helix, 41% strand | O34835 |
Ligands and binding sites
- MLC · Malonyl-coenzyme A · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.64 | 0.89 | 23 | MLC |
| 2 | 100 | 0.61 | 0.87 | 21 | MLC |
Interfaces
1 interface between chains.
- A–B · 1221 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 2F3X · Crystal structure of FapR (in complex with effector)- a global regulator of fatty acid… · the same entry in another collection · chain A against A, TM-score 1.00
- O34835 · AlphaFold monomer V2.0 prediction for transcription factor fapr (O34835) · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O34835
- Elsewhere: RCSB PDB 2F3X · PDBe 2F3X · UniProt O34835
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