MolNFT v1 · #3636 · protein
Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy
1CYL: “Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR…”. Solution nmr, 1 pocket (best druggability 0.35). MolNFT v1 #3636 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1CYL
- Type
- protein
- Length
- 129 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-4
- UniProt
- P05112
- Pockets
- 1 · best druggability 0.35
Structure
solution nmr · 1 distinct chain · 59% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-4 | protein | 129 | 59% helix, 2% strand | P05112 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.35 | 0.76 | 17 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1CYL · Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed… · the same entry in another collection · chain A against A, TM-score 1.00
- P05112 · AlphaFold monomer V2.0 prediction for interleukin-4 (P05112) · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05112
- Elsewhere: RCSB PDB 1CYL · PDBe 1CYL · UniProt P05112
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