MolNFT v1 · #36294 · protein
Three-dimensional structure of two crystal forms of Fab R19.9, from a monoclonal anti-arsonate antibody
2F19 · IGG2B-kappa R19.9 Fab (light chain): “Three-dimensional structure of two crystal forms of Fab R19.9, from a monoclonal anti-arsonate antibody”. X-ray diffraction, 3 pockets (best druggability 0.53). MolNFT v1 #36294 on GenesisL1: 3D…
- PDB
- 2F19
- Type
- protein
- Length
- 435 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IGG2B-kappa R19.9 Fab (light chain); IGG2B-kappa R19.9 Fab (heavy chain)
- UniProt
- P01837
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IGG2B-kappa R19.9 Fab (light chain) | protein | 214 | 6% helix, 48% strand | P01837 |
| H | IGG2B-kappa R19.9 Fab (heavy chain) | protein | 221 | 3% helix, 49% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 306 | 0.53 | 0.75 | 39 | empty |
| 2 | 98 | 0.39 | 0.76 | 17 | empty |
| 3 | 56 | 0.29 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- L–H · 1974 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 2F19 · Three-dimensional structure of two crystal forms of Fab R19.9, from a monoclonal… · the same entry in another collection · chain L against L, TM-score 1.00
- P01837 · AlphaFold monomer V2.0 prediction for immunoglobulin kappa constant (P01837) · a predicted model of the same protein · chain L against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01837
- Elsewhere: RCSB PDB 2F19 · PDBe 2F19 · UniProt P01837
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