MolNFT v1 · #36090 · protein
Structure of RV1264N, the regulatory domain of the mycobacterial adenylyl cylcase RV1264, at pH 6.0
2EV1 · Hypothetical protein RV1264/MT1302: “Structure of RV1264N, the regulatory domain of the mycobacterial adenylyl cylcase RV1264, at pH 6.0”. X-ray diffraction, 1 ligand (OLA), 3 pockets (best druggability 0.82). MolNFT v1 #36090 on…
- PDB
- 2EV1
- Type
- protein
- Length
- 366 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein RV1264/MT1302
- EC
- 4.6.1.1
- UniProt
- Q11055
- Ligands
- OLA
- Pockets
- 3 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical protein RV1264/MT1302 (EC 4.6.1.1) | protein | 185 | 70% helix, 2% strand | Q11055 |
| B | Hypothetical protein RV1264/MT1302 (EC 4.6.1.1) | protein | 181 | 70% helix, 2% strand | Q11055 |
Ligands and binding sites
- OLA · Oleic acid · ligand · 2 copies · chains A, B
- 1PE · Pentaethylene glycol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 345 | 0.82 | 0.91 | 58 | OLA |
| 2 | 299 | 0.79 | 0.89 | 48 | OLA |
| 3 | 69 | 0.47 | 0.83 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 3235 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2EV1 · Structure of Rv1264N, the regulatory domain of the mycobacterial adenylyl cylcase Rv1264… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q11055
- Elsewhere: RCSB PDB 2EV1 · PDBe 2EV1 · UniProt Q11055
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