MolNFT v1 · #36026 · protein

Atomic structure of the N-terminal SH3 domain of mouse beta PIX,P21-activated kinase (pak)-interacting exchange factor

2ESW · Rho guanine nucleotide exchange factor 7: “Atomic structure of the N-terminal SH3 domain of mouse beta PIX,P21-activated kinase (pak)-interacting…”. X-ray diffraction, 2 ligands (HG, CL). MolNFT v1 #36026 on GenesisL1: 3D structure…

PDB: 2ESW
Type: protein
Length: 117 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rho guanine nucleotide exchange factor 7
UniProt: Q9ES28
Ligands: HG, CL

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rho guanine nucleotide exchange factor 7	protein	60	5% helix, 48% strand	Q9ES28
B	Rho guanine nucleotide exchange factor 7	protein	57	5% helix, 51% strand	Q9ES28

Ligands and binding sites

HG · Mercury (II) ion · metal · 6 copies · chains A, B
CL · Chloride ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 439 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

2ESW · Atomic structure of the N-terminal SH3 domain of mouse beta PIX,p21-activated kinase… · the same entry in another collection · chain A against A, TM-score 1.00
Q9ES28 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 7 (Q9ES28) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9ES28
Elsewhere: RCSB PDB 2ESW · PDBe 2ESW · UniProt Q9ES28

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