MolNFT v1 · #35821 · protein
Crystal structure analysis of the radixin ferm domain complexed with adhesion molecule CD43
2EMS: “Crystal structure analysis of the radixin ferm domain complexed with adhesion molecule CD43”. X-ray diffraction, 6 pockets (best druggability 0.70). MolNFT v1 #35821 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2EMS
- Type
- protein
- Length
- 331 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Radixin; Leukosialin
- UniProt
- P26043, P15702
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Radixin | protein | 316 | 38% helix, 24% strand | P26043 |
| B | Leukosialin | protein | 15 | 0% helix, 27% strand | P15702 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 622 | 0.70 | 0.78 | 61 | empty |
| 2 | 117 | 0.51 | 0.81 | 17 | empty |
| 3 | 67 | 0.41 | 0.80 | 12 | empty |
| 4 | 64 | 0.33 | 0.77 | 19 | empty |
| 5 | 80 | 0.31 | 0.73 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 620 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2EMS · Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule… · the same entry in another collection · chain B against B, TM-score 1.00
- P26043 · AlphaFold monomer V2.0 prediction for radixin (P26043) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P15702 · AlphaFold monomer V2.0 prediction for leukosialin (P15702) · a predicted model of the same protein · chain B against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26043
- Every structure of UniProt P15702
- Elsewhere: RCSB PDB 2EMS · PDBe 2EMS · UniProt P26043 · UniProt P15702
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.