MolNFT v1 · #3581 · protein
Human CDC25B catalytic domain without ion in catalytic site
1CWR · Protein (M-phase inducer phosphatase 2 (CDC25B)): “Human CDC25B catalytic domain without ion in catalytic site”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.48). MolNFT v1 #3581 on GenesisL1: 3D structure…
- PDB
- 1CWR
- Type
- protein
- Length
- 177 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (M-phase inducer phosphatase 2 (CDC25B))
- EC
- 3.1.3.48
- UniProt
- P30305
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (M-phase inducer phosphatase 2 (CDC25B)) (EC 3.1.3.48) | protein | 177 | 32% helix, 17% strand | P30305 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.48 | 0.79 | 17 | BME |
| 2 | 83 | 0.42 | 0.79 | 22 | empty |
| 3 | 67 | 0.35 | 0.77 | 17 | empty |
Modifications
Observed in the structure: 1 covalent, 1 disulfide (additive adduct, disulfide).
Compared structures
- 1CWR · Human CDC25B catalytic domain without ion in catalytic site · the same entry in another collection · chain A against A, TM-score 1.00
- P30305 · AlphaFold monomer V2.0 prediction for M-phase inducer phosphatase 2 (P30305) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30305
- Elsewhere: RCSB PDB 1CWR · PDBe 1CWR · UniProt P30305
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