MolNFT v1 · #35701 · protein

Crystal structure of APPL1 ptb domain at 1.8A

2EJ8 · Dcc-interacting protein 13 alpha: “Crystal structure of APPL1 ptb domain at 1.8A”. X-ray diffraction, 2 pockets (best druggability 0.79). MolNFT v1 #35701 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2EJ8
Type: protein
Length: 264 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dcc-interacting protein 13 alpha
UniProt: Q9UKG1
Pockets: 2 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dcc-interacting protein 13 alpha	protein	133	28% helix, 44% strand	Q9UKG1
B	Dcc-interacting protein 13 alpha	protein	131	29% helix, 44% strand	Q9UKG1

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	724	0.79	0.83	56	empty
2	71	0.73	0.97	23	empty

Interfaces

1 interface between chains.

A–B · 934 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

2EJ8 · Crystal structure of APPL1 PTB domain at 1.8A · the same entry in another collection · chain A against A, TM-score 1.00
Q9UKG1 · AlphaFold monomer V2.0 prediction for dcc-interacting protein 13-alpha (Q9UKG1) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UKG1
Elsewhere: RCSB PDB 2EJ8 · PDBe 2EJ8 · UniProt Q9UKG1

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