MolNFT v1 · #35635 · protein
Crystal structure of humanized KR127 Fab
2EH7 · Humanized KR127 Fab, light chain: “Crystal structure of humanized KR127 Fab”. X-ray diffraction, 7 pockets (best druggability 0.58). MolNFT v1 #35635 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2EH7
- Type
- protein
- Length
- 437 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Humanized KR127 Fab, light chain; Humanized KR127 Fab, heavy chain
- Pockets
- 7 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Humanized KR127 Fab, light chain | protein | 219 | 6% helix, 48% strand | — |
| H | Humanized KR127 Fab, heavy chain | protein | 218 | 7% helix, 50% strand | — |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 426 | 0.58 | 0.75 | 52 | empty |
| 2 | 57 | 0.53 | 0.88 | 20 | empty |
| 3 | 61 | 0.40 | 0.80 | 12 | empty |
| 4 | 79 | 0.35 | 0.76 | 15 | empty |
| 5 | 95 | 0.35 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- L–H · 1963 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 2EH7 · Crystal structure of humanized KR127 FAB · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2EH7 · PDBe 2EH7
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