MolNFT v1 · #35630 · protein
Mutant V18M structure of PH0725 from pyrococcus horikoshii OT3
2EH2 · Diphthine synthase: “Mutant V18M structure of PH0725 from pyrococcus horikoshii OT3”. X-ray diffraction, 2 ligands (SAH, SO4), 8 pockets (best druggability 0.74). MolNFT v1 #35630 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2EH2
- Type
- protein
- Length
- 530 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Diphthine synthase
- EC
- 2.1.1.98
- UniProt
- O58456
- Ligands
- SAH, SO4
- Pockets
- 8 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Diphthine synthase (EC 2.1.1.98) | protein | 265 | 37% helix, 23% strand | O58456 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · chains A
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 418 | 0.74 | 0.84 | 54 | SO4, SAH |
| 2 | 441 | 0.73 | 0.83 | 48 | MES |
| 3 | 140 | 0.40 | 0.74 | 18 | empty |
| 4 | 84 | 0.37 | 0.76 | 16 | empty |
| 5 | 102 | 0.37 | 0.74 | 21 | MES |
Interfaces
1 interface between chains.
- A–B · 2564 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O58456
- Elsewhere: RCSB PDB 2EH2 · PDBe 2EH2 · UniProt O58456
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