MolNFT v1 · #35617 · protein

Crystal structure of tamalin PDZ domain

2EGO · General receptor for phosphoinositides 1-associated…: “Crystal structure of tamalin PDZ domain”. X-ray diffraction, 3 pockets (best druggability 0.34). MolNFT v1 #35617 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2EGO
Type: protein
Length: 178 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: General receptor for phosphoinositides 1-associated scaffold protein
UniProt: Q8R4T5
Pockets: 3 · best druggability 0.34

Structure

x-ray diffraction · 2 distinct chains · 16% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	General receptor for phosphoinositides 1-associated scaffold protein	protein	88	16% helix, 41% strand	Q8R4T5
B	General receptor for phosphoinositides 1-associated scaffold protein	protein	90	17% helix, 42% strand	Q8R4T5

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.34	0.78	14	empty
2	81	0.34	0.75	13	empty
3	62	0.30	0.74	13	empty

Interfaces

1 interface between chains.

A–B · 675 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

2EGO · Crystal Structure of Tamalin PDZ Domain · the same entry in another collection · chain A against A, TM-score 1.00
Q8R4T5 · AlphaFold monomer V2.0 prediction for general receptor for phosphoinositides 1-associated… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8R4T5
Elsewhere: RCSB PDB 2EGO · PDBe 2EGO · UniProt Q8R4T5

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