MolNFT v1 · #35479 · protein
Crystal structure of T.TH. HB8 O-acetylserine sulfhydrylase complexed with 4-methylvalerate
2ECO · O-acetylserine (thiol)-lyase: “Crystal structure of T.TH. HB8 O-acetylserine sulfhydrylase complexed with 4-methylvalerate”. X-ray diffraction, 2 ligands (PLP, 4MV), 2 pockets (best druggability 0.68). MolNFT v1 #35479 on GenesisL1…
- PDB
- 2ECO
- Type
- protein
- Length
- 302 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- O-acetylserine (thiol)-lyase
- EC
- 2.5.1.47
- UniProt
- Q5SLE6
- Ligands
- PLP, 4MV
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | O-acetylserine (thiol)-lyase (EC 2.5.1.47) | protein | 302 | 43% helix, 18% strand | Q5SLE6 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 522 | 0.68 | 0.79 | 45 | 4MV |
| 2 | 62 | 0.38 | 0.79 | 13 | empty |
Modifications
Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 2ECO · Crystal Structure of T.th. HB8 O-acetylserine sulfhydrylase Complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SLE6
- Elsewhere: RCSB PDB 2ECO · PDBe 2ECO · UniProt Q5SLE6
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