MolNFT v1 · #35336 · protein

Crystal structure of the human HSP70 ATPase domain in complex with AMP-pnp

2E8A · Heat shock 70KDA protein 1A: “Crystal structure of the human HSP70 ATPase domain in complex with AMP-pnp”. X-ray diffraction, 2 ligands (ANP, MG), 1 pocket (best druggability 0.76). MolNFT v1 #35336 on GenesisL1: 3D structure…

PDB: 2E8A
Type: protein
Length: 380 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock 70KDA protein 1A
UniProt: Q5JQI4
Ligands: ANP, MG
Pockets: 1 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock 70KDA protein 1A	protein	380	41% helix, 28% strand	Q5JQI4

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	688	0.76	0.81	79	MG, ANP

Compared structures

2E8A · Crystal structure of the human Hsp70 ATPase domain in complex with AMP-PNP · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5JQI4
Elsewhere: RCSB PDB 2E8A · PDBe 2E8A · UniProt Q5JQI4

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