MolNFT v1 · #35222 · protein
Crystal structure of the ligand-binding region of the group III metabotropic glutamate receptor
2E4Z · Metabotropic glutamate receptor 7: “Crystal structure of the ligand-binding region of the group III metabotropic glutamate receptor”. X-ray diffraction, 3 pockets (best druggability 0.69). MolNFT v1 #35222 on GenesisL1: 3D…
- PDB
- 2E4Z
- Type
- protein
- Length
- 434 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metabotropic glutamate receptor 7
- UniProt
- P35400
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Metabotropic glutamate receptor 7 | protein | 434 | 37% helix, 20% strand | P35400 |
Ligands and binding sites
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 630 | 0.69 | 0.77 | 58 | MES |
| 2 | 60 | 0.64 | 0.93 | 16 | empty |
| 3 | 77 | 0.45 | 0.81 | 16 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 2E4Z · Crystal structure of the ligand-binding region of the group III metabotropic glutamate… · the same entry in another collection · chain A against A, TM-score 1.00
- P35400 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 7 (P35400) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35400
- Elsewhere: RCSB PDB 2E4Z · PDBe 2E4Z · UniProt P35400
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