MolNFT v1 · #35132 · protein
ASP81LEU enzyme iia from the lactose specific pts from lactococcus lactis
2E2A · Protein (enzyme iia): “ASP81LEU enzyme iia from the lactose specific pts from lactococcus lactis”. X-ray diffraction, 3 pockets (best druggability 0.34). MolNFT v1 #35132 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2E2A
- Type
- protein
- Length
- 307 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (enzyme iia)
- EC
- 2.7.1.69
- UniProt
- P23532
- Pockets
- 3 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 85% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Protein (enzyme iia) (EC 2.7.1.69) | protein | 104 | 87% helix, 0% strand | P23532 |
| C | Protein (enzyme iia) (EC 2.7.1.69) | protein | 99 | 84% helix, 0% strand | P23532 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.34 | 0.78 | 13 | empty |
| 2 | 67 | 0.29 | 0.73 | 15 | empty |
| 3 | 56 | 0.29 | 0.74 | 12 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1155 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 1139 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1124 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 2E2A · ASP81LEU enzyme iia from the lactose specific pts from lactococcus lactis · the same entry in another collection · chain B against B, TM-score 1.00
- P23532 · AlphaFold monomer V2.0 prediction for pts system lactose-specific eiia component (P23532) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23532
- Elsewhere: RCSB PDB 2E2A · PDBe 2E2A · UniProt P23532
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