MolNFT v1 · #3511 · protein
Crystal structure of repeats 16 and 17 of chicken brain alpha spectrin
1CUN · Protein (alpha spectrin): “Crystal structure of repeats 16 and 17 of chicken brain alpha spectrin”. X-ray diffraction, 7 pockets (best druggability 0.39). MolNFT v1 #3511 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1CUN
- Type
- protein
- Length
- 639 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (alpha spectrin)
- UniProt
- P07751
- Pockets
- 7 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 87% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Protein (alpha spectrin) | protein | 213 | 87% helix, 0% strand | P07751 |
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.39 | 0.79 | 13 | empty |
| 2 | 73 | 0.39 | 0.78 | 23 | empty |
| 3 | 58 | 0.38 | 0.80 | 12 | empty |
| 4 | 72 | 0.34 | 0.76 | 17 | empty |
| 5 | 75 | 0.34 | 0.76 | 17 | empty |
Interfaces
3 interfaces between chains.
- B–C · 469 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 468 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 467 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1CUN · Crystal structure of repeats 16 and 17 of chicken brain alpha spectrin · the same entry in another collection · chain A against A, TM-score 1.00
- P07751 · AlphaFold monomer V2.0 prediction for spectrin alpha chain, non- erythrocytic 1 (P07751) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07751
- Elsewhere: RCSB PDB 1CUN · PDBe 1CUN · UniProt P07751
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