MolNFT v1 · #35080 · protein
Mutant human ribonuclease 1 (R31L, R32L)
2E0J: “Mutant human ribonuclease 1 (R31L, R32L)”. X-ray diffraction, 4 pockets (best druggability 0.50). MolNFT v1 #35080 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2E0J
- Type
- protein
- Length
- 256 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonuclease
- EC
- 3.1.27.5
- UniProt
- P07998
- Pockets
- 4 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ribonuclease (EC 3.1.27.5) | protein | 128 | 20% helix, 38% strand | P07998 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.50 | 0.86 | 22 | empty |
| 2 | 56 | 0.37 | 0.80 | 18 | empty |
| 3 | 71 | 0.36 | 0.77 | 16 | empty |
| 4 | 73 | 0.31 | 0.74 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 728 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07998
- Elsewhere: RCSB PDB 2E0J · PDBe 2E0J · UniProt P07998
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