MolNFT v1 · #35069 · protein
Crystal structure of H369A mutant of yeast bleomycin hydrolase
2E01 · Cysteine proteinase 1: “Crystal structure of H369A mutant of yeast bleomycin hydrolase”. X-ray diffraction, 5 pockets (best druggability 0.66). MolNFT v1 #35069 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2E01
- Type
- protein
- Length
- 445 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine proteinase 1
- EC
- 3.4.22.40
- UniProt
- Q01532
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine proteinase 1 (EC 3.4.22.40) | protein | 445 | 44% helix, 17% strand | Q01532 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 294 | 0.66 | 0.82 | 36 | empty |
| 2 | 89 | 0.63 | 0.90 | 22 | empty |
| 3 | 117 | 0.42 | 0.76 | 19 | empty |
| 4 | 123 | 0.41 | 0.75 | 19 | empty |
| 5 | 107 | 0.39 | 0.76 | 21 | empty |
Compared structures
- 2E01 · Crystal structure of H369A mutant of yeast bleomycin hydrolase · the same entry in another collection · chain A against A, TM-score 1.00
- Q01532 · AlphaFold monomer V2.0 prediction for cysteine proteinase 1, mitochondrial (Q01532) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01532
- Elsewhere: RCSB PDB 2E01 · PDBe 2E01 · UniProt Q01532
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