MolNFT v1 · #34908 · protein
Crystal structure of a M-loop deletion variant of ment in the native conformation
2DUT · Heterochromatin-associated protein ment: “Crystal structure of a M-loop deletion variant of ment in the native conformation”. X-ray diffraction, 14 pockets (best druggability 0.75). MolNFT v1 #34908 on GenesisL1: 3D structure…
- PDB
- 2DUT
- Type
- protein
- Length
- 1,464 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heterochromatin-associated protein ment
- UniProt
- O73790
- Pockets
- 14 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Heterochromatin-associated protein ment | protein | 366 | 29% helix, 30% strand | O73790 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 640 | 0.75 | 0.81 | 70 | empty |
| 2 | 865 | 0.73 | 0.78 | 118 | empty |
| 3 | 463 | 0.62 | 0.76 | 36 | empty |
| 4 | 355 | 0.59 | 0.76 | 33 | empty |
| 5 | 88 | 0.54 | 0.85 | 19 | empty |
Interfaces
3 interfaces between chains.
- B–D · 908 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 845 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 552 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 2DUT · Crystal structure of a M-loop deletion variant of MENT in the native conformation · the same entry in another collection · chain A against A, TM-score 1.00
- O73790 · AlphaFold monomer V2.0 prediction for heterochromatin-associated protein ment (O73790) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O73790
- Elsewhere: RCSB PDB 2DUT · PDBe 2DUT · UniProt O73790
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