MolNFT v1 · #3486 · protein

Transition-state selectivity for a single oh group during catalysis by cytidine deaminase

1CTT: “Transition-state selectivity for a single oh group during catalysis by cytidine deaminase”. X-ray diffraction, 2 ligands (DHZ, ZN), 2 pockets (best druggability 0.41). MolNFT v1 #3486 on GenesisL1: 3D structure, binding sites and…

PDB: 1CTT
Type: protein
Length: 294 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytidine deaminase
EC: 3.5.4.5
UniProt: P0ABF6
Ligands: DHZ, ZN
Pockets: 2 · best druggability 0.41

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytidine deaminase (EC 3.5.4.5)	protein	294	36% helix, 19% strand	P0ABF6

Ligands and binding sites

DHZ · 3,4-dihydro-1H-pyrimidin-2-one nucleoside · ligand · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	130	0.41	0.75	27	empty
2	60	0.33	0.77	16	DHZ

Compared structures

1CTT · Transition-state selectivity for a single oh group during catalysis by cytidine deaminase · the same entry in another collection · chain A against A, TM-score 1.00
P0ABF6 · AlphaFold monomer V2.0 prediction for cytidine deaminase (P0ABF6) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0ABF6
Elsewhere: RCSB PDB 1CTT · PDBe 1CTT · UniProt P0ABF6

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