MolNFT v1 · #34806 · protein
Docking and dimerization domain (D/D) of the type II-alpha regulatory subunity of protein kinase a (PKA) in complex with a peptide from an a-kinase anchoring protein
2DRN · Camp-dependent protein kinase type II-alpha regulatory…: “Docking and dimerization domain (D/D) of the type II-alpha regulatory subunity of protein kinase a (PKA) in…”. Solution nmr, 2 pockets (best druggability 0.43). MolNFT v1…
- PDB
- 2DRN
- Type
- protein
- Length
- 116 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent protein kinase type II-alpha regulatory subunit; 24-residues peptide from…
- EC
- 2.7.1.37
- UniProt
- P12368, Q14572
- Pockets
- 2 · best druggability 0.43
Structure
solution nmr · 2 distinct chains · 61% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Camp-dependent protein kinase type II-alpha regulatory subunit (EC 2.7.1.37) | protein | 46 | 59% helix, 0% strand | P12368 |
| C | 24-residues peptide from an a-kinase anchoring protein | protein | 24 | 67% helix, 0% strand | Q14572 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.43 | 0.78 | 16 | empty |
| 2 | 67 | 0.34 | 0.76 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 829 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 446 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 309 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2DRN · Docking and dimerization domain (D/D) of the Type II-alpha regulatory subunity of protein… · the same entry in another collection · chain A against A, TM-score 1.00
- P12368 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type II-alpha… · a predicted model of the same protein · chain A against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12368
- Every structure of UniProt Q14572
- Elsewhere: RCSB PDB 2DRN · PDBe 2DRN · UniProt P12368 · UniProt Q14572
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