MolNFT v1 · #34783 · protein
Crystal structure of dihydropteroate synthase (folp) from thermus thermophilus HB8
2DQW: “Crystal structure of dihydropteroate synthase (folp) from thermus thermophilus HB8”. X-ray diffraction, 3 pockets (best druggability 0.59). MolNFT v1 #34783 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2DQW
- Type
- protein
- Length
- 497 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydropteroate synthase
- EC
- 2.5.1.15
- UniProt
- Q5SLV2
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydropteroate synthase (EC 2.5.1.15) | protein | 250 | 46% helix, 16% strand | Q5SLV2 |
| B | Dihydropteroate synthase (EC 2.5.1.15) | protein | 247 | 44% helix, 17% strand | Q5SLV2 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 214 | 0.59 | 0.81 | 28 | empty |
| 2 | 176 | 0.58 | 0.81 | 30 | empty |
| 3 | 57 | 0.33 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1176 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2DQW · Crystal Structure of Dihydropteroate Synthase (FolP) from Thermus thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SLV2
- Elsewhere: RCSB PDB 2DQW · PDBe 2DQW · UniProt Q5SLV2
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