MolNFT v1 · #34723 · protein
Structural basis for the recognition of LYS48-linked polyubiquitin chain by the josephin domain of ataxin-3, a putative deubiquitinating enzyme
2DOS: “Structural basis for the recognition of LYS48-linked polyubiquitin chain by the josephin domain of ataxin-3…”. Solution nmr, 3 pockets (best druggability 0.49). MolNFT v1 #34723 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2DOS
- Type
- protein
- Length
- 171 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ataxin-3
- EC
- 3.4.22.-
- UniProt
- P54252
- Pockets
- 3 · best druggability 0.49
Structure
solution nmr · 1 distinct chain · 38% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ataxin-3 (EC 3.4.22.-) | protein | 171 | 38% helix, 19% strand | P54252 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 220 | 0.49 | 0.75 | 32 | empty |
| 2 | 74 | 0.48 | 0.83 | 17 | empty |
| 3 | 97 | 0.35 | 0.74 | 23 | empty |
Compared structures
- 2DOS · Structural basis for the recognition of Lys48-linked polyubiquitin chain by the Josephin… · the same entry in another collection · chain A against A, TM-score 1.00
- P54252 · AlphaFold monomer V2.0 prediction for ataxin-3 (P54252) · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54252
- Elsewhere: RCSB PDB 2DOS · PDBe 2DOS · UniProt P54252
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