MolNFT v1 · #34705 · protein

Solution structure of rsgi ruh-065, a uba domain from human cdna

2DO6 · E3 ubiquitin-protein ligase cbl-B: “Solution structure of rsgi ruh-065, a uba domain from human cdna”. Solution nmr, 1 pocket (best druggability 0.30). MolNFT v1 #34705 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2DO6
Type: protein
Length: 106 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E3 ubiquitin-protein ligase cbl-B
EC: 6.3.2.-
UniProt: Q13191
Pockets: 1 · best druggability 0.30

Structure

solution nmr · 1 distinct chain · 55% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	E3 ubiquitin-protein ligase cbl-B (EC 6.3.2.-)	protein	53	55% helix, 0% strand	Q13191

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.30	0.74	22	empty

Interfaces

1 interface between chains.

A–B · 477 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

2DO6 · Solution structure of RSGI RUH-065, a UBA domain from human cDNA · the same entry in another collection · chain A against A, TM-score 1.00
Q13191 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase cbl-B (Q13191) · a predicted model of the same protein · chain B against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13191
Elsewhere: RCSB PDB 2DO6 · PDBe 2DO6 · UniProt Q13191

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