MolNFT v1 · #34628 · protein

Solution structure of the SH2 domain of human protein vav-2

2DLZ: “Solution structure of the SH2 domain of human protein vav-2”. Solution nmr, 1 pocket (best druggability 0.29). MolNFT v1 #34628 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2DLZ
Type: protein
Length: 118 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein vav-2
UniProt: P52735
Pockets: 1 · best druggability 0.29

Structure

solution nmr · 1 distinct chain · 18% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein vav-2	protein	118	18% helix, 24% strand	P52735

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	64	0.29	0.74	16	empty

Compared structures

2DLZ · Solution structure of the SH2 domain of human protein vav-2 · the same entry in another collection · chain A against A, TM-score 1.00
P52735 · AlphaFold monomer V2.0 prediction for guanine nucleotide exchange factor VAV2 (P52735) · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52735
Elsewhere: RCSB PDB 2DLZ · PDBe 2DLZ · UniProt P52735

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