MolNFT v1 · #34439 · protein
Crystal structure of the putative trasncriptional regulator SCO7518 from streptomyces coelicolor A3(2)
2DG8 · Putative tetr-family transcriptional regulatory protein: “Crystal structure of the putative trasncriptional regulator SCO7518 from streptomyces coelicolor A3(2)”. X-ray diffraction, 5 pockets (best druggability 0.79). MolNFT v1…
- PDB
- 2DG8
- Type
- protein
- Length
- 698 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative tetr-family transcriptional regulatory protein
- Pockets
- 5 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative tetr-family transcriptional regulatory protein | protein | 175 | 79% helix, 0% strand | — |
| B | Putative tetr-family transcriptional regulatory protein | protein | 176 | 80% helix, 0% strand | — |
| C | Putative tetr-family transcriptional regulatory protein | protein | 174 | 78% helix, 0% strand | — |
| D | Putative tetr-family transcriptional regulatory protein | protein | 173 | 78% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1123 | 0.79 | 0.80 | 110 | empty |
| 2 | 113 | 0.73 | 0.93 | 29 | empty |
| 3 | 85 | 0.69 | 0.93 | 21 | empty |
| 4 | 200 | 0.52 | 0.77 | 31 | empty |
| 5 | 172 | 0.48 | 0.76 | 29 | empty |
Interfaces
4 interfaces between chains.
- A–D · 2020 Ų buried · 27 hydrogen bonds · protein-protein
- B–C · 1907 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 134 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 28 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2DG8 · Crystal structure of the putative trasncriptional regulator SCO7518 from Streptomyces… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2DG8 · PDBe 2DG8
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