MolNFT v1 · #34393 · protein
1510-N membrane protease specific for a stomatin homolog from pyrococcus horikoshii
2DEO · 441AA long hypothetical nfed protein: “1510-N membrane protease specific for a stomatin homolog from pyrococcus horikoshii”. X-ray diffraction, 7 pockets (best druggability 0.51). MolNFT v1 #34393 on GenesisL1: 3D structure, binding…
- PDB
- 2DEO
- Type
- protein
- Length
- 399 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 441AA long hypothetical nfed protein
- UniProt
- O59179
- Pockets
- 7 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 441AA long hypothetical nfed protein | protein | 199 | 37% helix, 23% strand | O59179 |
| B | 441AA long hypothetical nfed protein | protein | 200 | 39% helix, 23% strand | O59179 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 210 | 0.51 | 0.76 | 29 | empty |
| 2 | 134 | 0.49 | 0.79 | 18 | empty |
| 3 | 113 | 0.45 | 0.78 | 21 | empty |
| 4 | 71 | 0.43 | 0.81 | 14 | empty |
| 5 | 117 | 0.43 | 0.77 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 677 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 2DEO · 1510-N membrane protease specific for a stomatin homolog from Pyrococcus horikoshii · the same entry in another collection · chain A against A, TM-score 1.00
- O59179 · AlphaFold monomer V2.0 prediction for membrane-bound protease PH1510 (O59179) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59179
- Elsewhere: RCSB PDB 2DEO · PDBe 2DEO · UniProt O59179
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.