MolNFT v1 · #34328 · protein
The crystal structure of S603A mutated prolyl tripeptidyl aminopeptidase complexed with substrate
2DCM · Dipeptidyl aminopeptidase IV, putative: “The crystal structure of S603A mutated prolyl tripeptidyl aminopeptidase complexed with substrate”. X-ray diffraction, 1 ligand (GA0), 4 pockets (best druggability 0.71). MolNFT v1 #34328 on…
- PDB
- 2DCM
- Type
- protein
- Length
- 662 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dipeptidyl aminopeptidase IV, putative
- EC
- 3.4.14.-
- UniProt
- Q7MUW6
- Ligands
- GA0
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 15% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dipeptidyl aminopeptidase IV, putative (EC 3.4.14.-) | protein | 662 | 15% helix, 36% strand | Q7MUW6 |
Ligands and binding sites
- GA0 · Glycylalanyl-N-2-naphthyl-L-prolineamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 783 | 0.71 | 0.77 | 93 | GA0 |
| 2 | 220 | 0.47 | 0.74 | 32 | empty |
| 3 | 57 | 0.32 | 0.76 | 15 | empty |
| 4 | 67 | 0.29 | 0.74 | 14 | empty |
Compared structures
- 2DCM · The Crystal Structure of S603A Mutated Prolyl Tripeptidyl Aminopeptidase Complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q7MUW6 · AlphaFold monomer V2.0 prediction for prolyl tripeptidyl peptidase (Q7MUW6) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7MUW6
- Elsewhere: RCSB PDB 2DCM · PDBe 2DCM · UniProt Q7MUW6
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