MolNFT v1 · #34218 · protein

Solution structure of the smr domain of NEDD4-binding protein 2

2D9I: “Solution structure of the smr domain of NEDD4-binding protein 2”. Solution nmr, 2 pockets (best druggability 0.44). MolNFT v1 #34218 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2D9I
Type: protein
Length: 96 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NEDD4-binding protein 2
EC: 3.-.-.-
UniProt: Q86UW6
Pockets: 2 · best druggability 0.44

Structure

solution nmr · 1 distinct chain · 39% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NEDD4-binding protein 2 (EC 3.-.-.-)	protein	96	39% helix, 15% strand	Q86UW6

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.44	0.82	17	empty
2	53	0.30	0.76	20	empty

Compared structures

2D9I · Solution structure of the SMR domain of NEDD4-binding protein 2 · the same entry in another collection · chain A against A, TM-score 1.00
Q86UW6 · AlphaFold monomer V2.0 prediction for NEDD4-binding protein 2 (Q86UW6) · a predicted model of the same protein · chain A against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86UW6
Elsewhere: RCSB PDB 2D9I · PDBe 2D9I · UniProt Q86UW6

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