MolNFT v1 · #34203 · protein

Solution structure of the CNMP_BINDING domain of human rap guanine nucleotide exchange factor 6

2D93: “Solution structure of the CNMP_BINDING domain of human rap guanine nucleotide exchange factor 6”. Solution nmr, 1 pocket (best druggability 0.28). MolNFT v1 #34203 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2D93
Type: protein
Length: 134 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rap guanine nucleotide exchange factor 6
UniProt: Q8TEU7
Pockets: 1 · best druggability 0.28

Structure

solution nmr · 1 distinct chain · 19% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rap guanine nucleotide exchange factor 6	protein	134	19% helix, 29% strand	Q8TEU7

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.28	0.74	13	empty

Compared structures

2D93 · Solution structure of the cNMP_binding domain of human Rap guanine nucleotide exchange… · the same entry in another collection · chain A against A, TM-score 1.00
Q8TEU7 · AlphaFold monomer V2.0 prediction for rap guanine nucleotide exchange factor 6 (Q8TEU7) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TEU7
Elsewhere: RCSB PDB 2D93 · PDBe 2D93 · UniProt Q8TEU7

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