MolNFT v1 · #34186 · protein
Solution structure of the first brct domain of DNA-repair protein XRCC1
2D8M: “Solution structure of the first brct domain of DNA-repair protein XRCC1”. Solution nmr, 3 pockets (best druggability 0.36). MolNFT v1 #34186 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2D8M
- Type
- protein
- Length
- 129 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-repair protein XRCC1
- UniProt
- P18887
- Pockets
- 3 · best druggability 0.36
Structure
solution nmr · 1 distinct chain · 28% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-repair protein XRCC1 | protein | 129 | 28% helix, 15% strand | P18887 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.36 | 0.72 | 26 | empty |
| 2 | 109 | 0.35 | 0.73 | 17 | empty |
| 3 | 63 | 0.29 | 0.74 | 17 | empty |
Compared structures
- 2D8M · Solution structure of the first BRCT domain of DNA-repair protein XRCC1 · the same entry in another collection · chain A against A, TM-score 1.00
- P18887 · AlphaFold monomer V2.0 prediction for DNA repair protein XRCC1 (P18887) · a predicted model of the same protein · chain A against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18887
- Elsewhere: RCSB PDB 2D8M · PDBe 2D8M · UniProt P18887
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