MolNFT v1 · #34146 · protein
Crystal structure of translation initiation factor AIF2BETAGAMMA heterodimer
2D74 · Translation initiation factor 2 gamma subunit: “Crystal structure of translation initiation factor AIF2BETAGAMMA heterodimer”. X-ray diffraction, 1 ligand (ZN), 6 pockets (best druggability 0.71). MolNFT v1 #34146 on GenesisL1: 3D…
- PDB
- 2D74
- Type
- protein
- Length
- 540 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor 2 gamma subunit; Translation initiation factor 2 beta…
- UniProt
- Q8U082, Q8U3I5
- Ligands
- ZN
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translation initiation factor 2 gamma subunit | protein | 403 | 18% helix, 37% strand | Q8U082 |
| B | Translation initiation factor 2 beta subunit | protein | 137 | 31% helix, 13% strand | Q8U3I5 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 124 | 0.71 | 0.92 | 32 | empty |
| 2 | 388 | 0.61 | 0.77 | 49 | empty |
| 3 | 112 | 0.50 | 0.81 | 23 | empty |
| 4 | 176 | 0.49 | 0.77 | 30 | empty |
| 5 | 73 | 0.45 | 0.82 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1467 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 2D74 · Crystal structure of translation initiation factor aIF2betagamma heterodimer · the same entry in another collection · chain A against A, TM-score 1.00
- Q8U082 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit gamma… · a predicted model of the same protein · chain A against A, TM-score 0.88
- Q8U3I5 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit beta… · a predicted model of the same protein · chain B against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8U082
- Every structure of UniProt Q8U3I5
- Elsewhere: RCSB PDB 2D74 · PDBe 2D74 · UniProt Q8U082 · UniProt Q8U3I5
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