MolNFT v1 · #34119 · protein
Crystal structure of a tob-HCAF1 complex
2D5R · CCR4-not transcription complex subunit 7: “Crystal structure of a tob-HCAF1 complex”. X-ray diffraction, 4 pockets (best druggability 0.54). MolNFT v1 #34119 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2D5R
- Type
- protein
- Length
- 368 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CCR4-not transcription complex subunit 7; TOB1 protein
- UniProt
- Q9UIV1, P50616
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CCR4-not transcription complex subunit 7 | protein | 252 | 46% helix, 13% strand | Q9UIV1 |
| B | TOB1 protein | protein | 116 | 46% helix, 20% strand | P50616 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 276 | 0.54 | 0.76 | 31 | empty |
| 2 | 102 | 0.49 | 0.81 | 19 | empty |
| 3 | 179 | 0.49 | 0.76 | 27 | empty |
| 4 | 54 | 0.31 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 809 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2D5R · Crystal Structure of a Tob-hCaf1 Complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UIV1 · AlphaFold monomer V2.0 prediction for CCR4-not transcription complex subunit 7 (Q9UIV1) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P50616 · AlphaFold monomer V2.0 prediction for protein TOB1 (P50616) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UIV1
- Every structure of UniProt P50616
- Elsewhere: RCSB PDB 2D5R · PDBe 2D5R · UniProt Q9UIV1 · UniProt P50616
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