MolNFT v1 · #34092 · protein
Crystal structure of the ligand binding domain of the bacterial serine chemoreceptor tsr
2D4U · Methyl-accepting chemotaxis protein I: “Crystal structure of the ligand binding domain of the bacterial serine chemoreceptor tsr”. X-ray diffraction, 5 pockets (best druggability 0.63). MolNFT v1 #34092 on GenesisL1: 3D structure…
- PDB
- 2D4U
- Type
- protein
- Length
- 322 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methyl-accepting chemotaxis protein I
- UniProt
- P02942
- Pockets
- 5 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 85% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methyl-accepting chemotaxis protein I | protein | 167 | 85% helix, 0% strand | P02942 |
| B | Methyl-accepting chemotaxis protein I | protein | 155 | 85% helix, 0% strand | P02942 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 182 | 0.63 | 0.84 | 22 | empty |
| 2 | 206 | 0.62 | 0.82 | 21 | empty |
| 3 | 255 | 0.57 | 0.78 | 33 | empty |
| 4 | 229 | 0.48 | 0.75 | 33 | empty |
| 5 | 86 | 0.34 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1830 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2D4U · Crystal Structure of the ligand binding domain of the bacterial serine chemoreceptor Tsr · the same entry in another collection · chain A against A, TM-score 1.00
- P02942 · AlphaFold monomer V2.0 prediction for methyl-accepting chemotaxis protein I (P02942) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02942
- Elsewhere: RCSB PDB 2D4U · PDBe 2D4U · UniProt P02942
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