MolNFT v1 · #33921 · protein
Crystal structure of probable phosphoribosylglycinamide formyl transferase (PH0318) from pyrococcus horikoshii OT3
2CZG: “Crystal structure of probable phosphoribosylglycinamide formyl transferase (PH0318) from pyrococcus…”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.78). MolNFT v1 #33921 on GenesisL1: 3D structure, binding sites…
- PDB
- 2CZG
- Type
- protein
- Length
- 808 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoribosylglycinamide formyl transferase
- EC
- 2.1.2.-
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoribosylglycinamide formyl transferase (EC 2.1.2.-) | protein | 405 | 30% helix, 29% strand | — |
| B | Phosphoribosylglycinamide formyl transferase (EC 2.1.2.-) | protein | 403 | 31% helix, 30% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 120 | 0.78 | 0.97 | 34 | GOL |
| 2 | 648 | 0.70 | 0.78 | 64 | SO4 |
| 3 | 483 | 0.61 | 0.75 | 62 | SO4 |
| 4 | 53 | 0.40 | 0.81 | 14 | GOL |
Interfaces
1 interface between chains.
- A–B · 2756 Ų buried · 55 hydrogen bonds · protein-protein
Compared structures
- 2CZG · Crystal structure of Probable phosphoribosylglycinamide formyl transferase (PH0318) from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2CZG · PDBe 2CZG
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.