MolNFT v1 · #33909 · protein
Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from mus musculus (form-1 crystal)
2CZ2: “Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from mus musculus…”. X-ray diffraction, 1 ligand (GSH), 3 pockets (best druggability 0.67). MolNFT v1 #33909 on GenesisL1: 3D structure, binding…
- PDB
- 2CZ2
- Type
- protein
- Length
- 212 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maleylacetoacetate isomerase
- EC
- 5.2.1.2, 2.5.1.18
- UniProt
- Q9WVL0
- Ligands
- GSH
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maleylacetoacetate isomerase (EC 5.2.1.2, 2.5.1.18) | protein | 212 | 56% helix, 8% strand | Q9WVL0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 247 | 0.67 | 0.84 | 36 | GSH |
| 2 | 108 | 0.43 | 0.77 | 20 | empty |
| 3 | 51 | 0.30 | 0.76 | 17 | GOL |
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 2CZ2 · Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9WVL0 · AlphaFold monomer V2.0 prediction for maleylacetoacetate isomerase (Q9WVL0) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WVL0
- Elsewhere: RCSB PDB 2CZ2 · PDBe 2CZ2 · UniProt Q9WVL0
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