MolNFT v1 · #33870 · protein
Crystal structure of mouse amf / phosphate complex
2CXN · Glucose-6-phosphate isomerase: “Crystal structure of mouse amf / phosphate complex”. X-ray diffraction, 1 ligand (PO4), 11 pockets (best druggability 0.76). MolNFT v1 #33870 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2CXN
- Type
- protein
- Length
- 1,114 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose-6-phosphate isomerase
- EC
- 5.3.1.9
- UniProt
- P06745
- Ligands
- PO4
- Pockets
- 11 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 55% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glucose-6-phosphate isomerase (EC 5.3.1.9) | protein | 557 | 55% helix, 13% strand | P06745 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 938 | 0.76 | 0.79 | 62 | empty |
| 2 | 505 | 0.71 | 0.81 | 54 | empty |
| 3 | 345 | 0.69 | 0.83 | 50 | PO4 |
| 4 | 78 | 0.45 | 0.81 | 17 | empty |
| 5 | 113 | 0.43 | 0.77 | 14 | GOL |
Interfaces
1 interface between chains.
- A–B · 6771 Ų buried · 94 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06745
- Elsewhere: RCSB PDB 2CXN · PDBe 2CXN · UniProt P06745
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