MolNFT v1 · #33853 · protein

Crystal structure of a putative trans-editing enzyme for prolyl tRNA synthetase

2CX5: “Crystal structure of a putative trans-editing enzyme for prolyl tRNA synthetase”. X-ray diffraction, 7 pockets (best druggability 0.70). MolNFT v1 #33853 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2CX5
Type: protein
Length: 628 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: A putative trans-editing enzyme
UniProt: Q5SHN1
Pockets: 7 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	A putative trans-editing enzyme	protein	157	33% helix, 24% strand	Q5SHN1

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	504	0.70	0.80	55	empty
2	249	0.64	0.82	42	empty
3	162	0.55	0.80	30	empty
4	153	0.54	0.80	30	empty
5	104	0.47	0.80	20	empty

Interfaces

3 interfaces between chains.

A–C · 747 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 710 Å² buried · 6 hydrogen bonds · protein-protein
C–D · 307 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2CX5 · Crystal structure of a putative trans-editing enzyme for prolyl tRNA synthetase · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SHN1
Elsewhere: RCSB PDB 2CX5 · PDBe 2CX5 · UniProt Q5SHN1

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