MolNFT v1 · #33831 · protein
X-ray crystal structure analysis of recombinant wild-type canine milk lysozyme (apo-type)
2CWI · Lysozyme C, milk isozyme: “X-ray crystal structure analysis of recombinant wild-type canine milk lysozyme (apo-type)”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.65). MolNFT v1 #33831 on GenesisL1: 3D…
- PDB
- 2CWI
- Type
- protein
- Length
- 258 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lysozyme C, milk isozyme
- EC
- 3.2.1.17
- UniProt
- P81708
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Lysozyme C, milk isozyme (EC 3.2.1.17) | protein | 129 | 36% helix, 9% strand | P81708 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 266 | 0.65 | 0.82 | 40 | empty |
| 2 | 81 | 0.36 | 0.76 | 20 | empty |
| 3 | 83 | 0.34 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 446 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 2CWI · X-ray crystal structure analysis of recombinant wild-type canine milk lysozyme (apo-type) · the same entry in another collection · chain A against A, TM-score 1.00
- P81708 · AlphaFold monomer V2.0 prediction for lysozyme C, milk isozyme (P81708) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P81708
- Elsewhere: RCSB PDB 2CWI · PDBe 2CWI · UniProt P81708
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