MolNFT v1 · #33822 · protein

Crystal structure of human TIM44 C-terminal domain

2CW9 · Translocase of inner mitochondrial membrane: “Crystal structure of human TIM44 C-terminal domain”. X-ray diffraction, 2 pockets (best druggability 0.44). MolNFT v1 #33822 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2CW9
Type: protein
Length: 182 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translocase of inner mitochondrial membrane
UniProt: O43615
Pockets: 2 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Translocase of inner mitochondrial membrane	protein	182	43% helix, 33% strand	O43615

Ligands and binding sites

1PE · Pentaethylene glycol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	136	0.44	0.75	20	empty
2	55	0.36	0.79	10	empty

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

2CW9 · Crystal structure of human Tim44 C-terminal domain · the same entry in another collection · chain A against A, TM-score 1.00
O43615 · AlphaFold monomer V2.0 prediction for mitochondrial import inner membrane translocase… · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43615
Elsewhere: RCSB PDB 2CW9 · PDBe 2CW9 · UniProt O43615

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