MolNFT v1 · #33790 · protein
Crystal structure of a hypothetical protein from thermus thermophilus HB8
2CV9 · Hypothetical protein TTHA0625: “Crystal structure of a hypothetical protein from thermus thermophilus HB8”. X-ray diffraction, 10 pockets (best druggability 0.59). MolNFT v1 #33790 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2CV9
- Type
- protein
- Length
- 1,008 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein TTHA0625
- UniProt
- Q5SKL8
- Pockets
- 10 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Hypothetical protein TTHA0625 | protein | 252 | 26% helix, 31% strand | Q5SKL8 |
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 285 | 0.59 | 0.78 | 32 | empty |
| 2 | 417 | 0.58 | 0.75 | 36 | empty |
| 3 | 262 | 0.57 | 0.78 | 34 | empty |
| 4 | 260 | 0.56 | 0.77 | 34 | empty |
| 5 | 239 | 0.56 | 0.78 | 35 | empty |
Interfaces
4 interfaces between chains.
- A–D · 1620 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 1590 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 121 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 49 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified (engineered).
Compared structures
- 2CV9 · Crystal structure of a hypothetical protein from Thermus thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SKL8
- Elsewhere: RCSB PDB 2CV9 · PDBe 2CV9 · UniProt Q5SKL8
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