MolNFT v1 · #33605 · protein

High-resolution crystal structure of cytochrome P450-cam

2CPP: “High-resolution crystal structure of cytochrome P450-cam”. X-ray diffraction, 2 ligands (HEM, CAM), 3 pockets (best druggability 0.86). MolNFT v1 #33605 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2CPP
Type: protein
Length: 405 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P450-cam
EC: 1.14.15.1
UniProt: P00183
Ligands: HEM, CAM
Pockets: 3 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P450-cam (EC 1.14.15.1)	protein	405	52% helix, 11% strand	P00183

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
CAM · Camphor · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	453	0.86	0.93	49	HEM, CAM
2	85	0.43	0.80	16	empty
3	50	0.31	0.76	14	empty

Compared structures

2CPP · High-resolution crystal structure of cytochrome P450-cam · the same entry in another collection · chain A against A, TM-score 1.00
P00183 · AlphaFold monomer V2.0 prediction for camphor 5-monooxygenase (P00183) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00183
Elsewhere: RCSB PDB 2CPP · PDBe 2CPP · UniProt P00183

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.