MolNFT v1 · #33576 · protein

Solution structure of the first and second zf-C2H2 domain of zinc finger protein 435

2COT: “Solution structure of the first and second zf-C2H2 domain of zinc finger protein 435”. Solution nmr, 1 ligand (ZN), 1 pocket (best druggability 0.60). MolNFT v1 #33576 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2COT
Type: protein
Length: 77 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zinc finger protein 435
UniProt: Q9H4T2
Ligands: ZN
Pockets: 1 · best druggability 0.60

Structure

solution nmr · 1 distinct chain · 23% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Zinc finger protein 435	protein	77	23% helix, 8% strand	Q9H4T2

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	358	0.60	0.77	37	empty

Compared structures

2COT · Solution structure of the first and second zf-C2H2 domain of Zinc finger protein 435 · the same entry in another collection · chain A against A, TM-score 1.00
Q9H4T2 · AlphaFold monomer V2.0 prediction for zinc finger and scan domain- containing protein 16… · a predicted model of the same protein · chain A against A, TM-score 0.33

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H4T2
Elsewhere: RCSB PDB 2COT · PDBe 2COT · UniProt Q9H4T2

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